In an effort to get medical help for Alabama tenant farmers, their nurse, Miss Evers, convinces them to join a government study to treat venereal disease. When the money runs out, Nurse Evers is faced with a difficult decision: to tell the men that they are no longer being treated and that they are now part of a research study to see what untreated syphilis will do to them, or follow the lead of the doctor she respects and the tenets of the nursing profession. Nurse Evers follows the advice of her advisors, and with the understanding that the study can help thousands more, she does not tell the men they are no longer receiving medication. She does this with the assurance that as soon as education becomes available, her men will be the first to receive it. But after fourteen years of caring for her patients as if they were family, when medication is finally available, it is denied to her study group. Nurse Evers, devastated at the news and starting to watch her men die, can no longer keep silent. Shunned for her silence of 14 years, Nurse Evers holds her head up and explains the reasons and emotions that kept her in the study and kept her caring for her men. Some of them forgive her, others do not, as Nurse Evers tries to put back a world broken by prejudice, disease, time and trust.